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d[Cha4]-AVP TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
d[Cha4]-AVP TFA 是一种有效的选择性加压素 (AVP)V1b受体激动剂,对人V1b受体的Ki为 1.2 nM。d[Cha4]-AVP TFA 对 V1b 受体的选择性高于对人类 V1a 受体、V2 受体和催产素受体。
生物活性

d[Cha4]-AVP TFA is a potent and selectivevasopressin (AVP) V1b receptoragonist with aKiof 1.2 nM forhuman V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].

IC50& Target

Ki: 1.2 nM (vasopressin V1B receptor), 151 nM (vasopressin V1A receptor), 240 nM (Oxytocin receptor), 750 nM (vasopressin V2 receptor)

体外研究
(In Vitro)

d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pKivalues of 9.68 and 7.68, respectively[2].
d[Cha4]-AVP stimulates [Ca2+]iincrease in hV1b-CHO cells with a pEC50value of 10.05. d[Cha4]-AVP shows pEC50values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31)[2].

分子量

1208.33

Formula

C52H72F3N13O13S2

Sequence

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)

Sequence Shortening

{Mpa}YF{Cha}NCPRG-NH2 (Disulfide bridge:Mpa1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.