7,8-Dihydroneopterin 是一种炎症标记,通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。
生物活性 | 7,8-Dihydroneopterin, an inflammation marker, induces cellularapoptosisin astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1]. |
IC50& Target | iNOS | Human Endogenous Metabolite |
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体外研究 (In Vitro) | 7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y)[1]. 7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes[1].
Cell Viability Assay[1] Cell Line: | Astrocytic cell line U373MG | Concentration: | 0.1, 0.5, 1, 2.5, 5 mM | Incubation Time: | 2 days and 5 days | Result: | After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM. After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Powder | -20°C | 3 years | In solvent | -80°C | 6 months | | -20°C | 1 month |
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