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L-NIL hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-NIL hydrochloride图片
CAS NO:150403-89-7
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
L-NIL hydrochloride 是诱导型一氧化氮合成酶(iNOS)的抑制剂，其对 miNOS 的IC50值为3.3 μM。
生物活性

L-NIL hydrochloride is aninducibleNO synthaseinhibitor, with anIC50of 3.3 μM for miNOS[1][2][3].

IC50& Target

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[1].

体外研究
(In Vitro)

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[3].

体内研究
(In Vivo)

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].

Animal Model:Adult male Balb/c (20-25 g)[1].
Dosage:10 and 30 mg/kg.
Administration:Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result:Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
分子量

223.70

Formula

C8H18ClN3O2

CAS 号

150403-89-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.