CAS NO: | 159190-45-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | L-NIL dihydrochloride is aninducibleNO synthaseinhibitor, with anIC50of 3.3 μM for miNOS[1][2][3]. | ||||||||
IC50& Target | IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3]. | ||||||||
体外研究 (In Vitro) | L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2]. | ||||||||
体内研究 (In Vivo) | L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].
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分子量 | 260.16 | ||||||||
Formula | C8H19Cl2N3O2 | ||||||||
CAS 号 | 159190-45-1 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |