CAS NO: | 54447-84-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | c-di-AMP (Cyclic diadenylate) is aSTINGagonist, which binds to the transmembrane proteinSTINGthereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also abacterialsecond messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. | ||||||||||||||||
IC50& Target | STING[3] | ||||||||||||||||
体外研究 (In Vitro) | c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria includingS. aureus,L. monocytogenes,S. pyogenes, andMycobacterium spp[1]. | ||||||||||||||||
分子量 | 658.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H24N10O12P2 | ||||||||||||||||
CAS 号 | 54447-84-6 | ||||||||||||||||
中文名称 | 环二腺苷酸 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: H2O : 3.33 mg/mL(5.06 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |