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c-di-AMP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
c-di-AMP图片
CAS NO:54447-84-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
环二腺苷酸
Cyclic diadenylate
Cyclic-di-AMP
产品介绍
c-di-AMP (Cyclic diadenylate) 是STING激动剂,其与 STING 结合,从而激活 TBK3-IRF3 信号传导途径,随后引发 I 型 IFN 和 TNF 产生。c-di-AMP (Cyclic diadenylate) 是一种细菌第二信使,主要在革兰氏阳性细菌中,可调节细胞生长,存活以及毒力。c-di-AMP (Cyclic diadenylate) 也调节宿主免疫反应。c-di-AMP (Cyclic diadenylate) 可作为一种有效的粘膜佐剂,刺激体液和细胞反应。
生物活性

c-di-AMP (Cyclic diadenylate) is aSTINGagonist, which binds to the transmembrane proteinSTINGthereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also abacterialsecond messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50& Target

STING[3]

体外研究
(In Vitro)

c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria includingS. aureus,L. monocytogenes,S. pyogenes, andMycobacterium spp[1].
c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

分子量

658.41

性状

Solid

Formula

C20H24N10O12P2

CAS 号

54447-84-6

中文名称

环二腺苷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 3.33 mg/mL(5.06 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.5188 mL7.5941 mL15.1881 mL
5 mM0.3038 mL1.5188 mL3.0376 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。