包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | STINGagonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with apEC50andpEC50of 7.5 and 9.5, respectively.STINGagonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment ofcancer[1]. |
IC50& Target | STING[1] |
体外研究 (In Vitro) | STING agonist-3 trihydrochloride exhibits a pEC50value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter[1].STING agonist-3 trihydrochloride exhibits a pIC50value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING[1]. |
分子量 | 860.19 |
Formula | C37H45Cl3N12O6 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |