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STING agonist-3 trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
STING agonist-3 trihydrochloride图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
STING agonist-3 trihydrochloride 源于专利 WO2017175147A1 (实施例10),是一种选择性和非核苷酸的小分子STING激动剂,pEC50pIC50分别为 7.5 和 9.5。STING agonist-3 trihydrochloride 具有持久的抗肿瘤作用,并且在改善癌症研究方面具有巨大潜力。
生物活性

STINGagonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with apEC50andpEC50of 7.5 and 9.5, respectively.STINGagonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment ofcancer[1].

IC50& Target

STING[1]

体外研究
(In Vitro)

STING agonist-3 trihydrochloride exhibits a pEC50value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter[1].
STING agonist-3 trihydrochloride exhibits a pIC50value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING[1].

分子量

860.19

Formula

C37H45Cl3N12O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.