STING agonist-12

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STING agonist-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2259624-71-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

STING agonist-12 (Compound 53) 是一种口服有效的人STING激活剂，EC₅₀为 185 nM。

生物活性

STINGagonist-12 (Compound 53) is a potent, orally active humanSTINGactivator with anEC₅₀of 185 nM^[1].

IC₅₀& Target

EC₅₀: 185 nM (STING)^[1]

体外研究
(In Vitro)

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells^[1].
STING agonist-12 is not active at mouse STING^[1].

体内研究
(In Vivo)

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life^[1].

Animal Model:

Balb/c mice (n=3)^[1]

Dosage:

5 or 10 mpk

Administration:

Lateral tail vein or oral gavage (Pharmacokinetic Analysis)

Result:

Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse^[1].

Route	DOSE (mpk)	AUC (ng/mL*h)	T_1/2 (h)	C_max (ng/mL)	V_d (mL/kg)	F (%)
IV	5	1215	1.41	1867	2689	NA
PO	10	2090	NA	1723	NA	86

分子量

490.88

性状

Solid

Formula

C₂₅H₁₉ClF₄N₂O₂

CAS 号

2259624-71-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 250 mg/mL(509.29 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0372 mL	10.1858 mL	20.3716 mL
5 mM	0.4074 mL	2.0372 mL	4.0743 mL
10 mM	0.2037 mL	1.0186 mL	2.0372 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。