(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of theGABA_Areceptorand inhibitsnAChandNMDA receptors^[1].

Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABA_Areceptor currents evoked by subsaturating concentrations of GABA^[1].
(S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABA_Areceptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors^[1].
In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors^[1].

374.78

C₁₆H₁₅ClN₆O₃

151776-26-0

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