CAS NO: | 230615-23-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selectiveα4β2 nicotine acetylcholine receptor (nAChR)partial agonist and fullα7nAChRagonist[1][2][3]. Varenicline Hydrochloride is also a potent partial agonist ofα6β2nAChRin striatum of rats with aKivalue of 0.12 nM[4]. | ||||||||||||||||
IC50& Target | nAChR[1] | ||||||||||||||||
体内研究 (In Vivo) | Varenicline (0.5-2 mg/kg/day; subcutaneous injection; twice daily; for 14 days; male Wistar rats) treatment shows a comparable significantly higher DRD2/3 availability in the ventral striatum of approximately 11%, while only the rats treated with 1 and 2 mg/kg/day dose shows significantly higher DRD2/3 availability in the dorsal striatum by 12.5% and 13.2%, respectively. Varenicline induces dose-dependent and sustained increases in striatal DRD2/3 in rats, particularly in the ventral striatum[1].
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Clinical Trial | |||||||||||||||||
分子量 | 247.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C13H14ClN3 | ||||||||||||||||
CAS 号 | 230615-23-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 50 mg/mL(201.84 mM;Need ultrasonic) DMSO : ≥ 2.5 mg/mL(10.09 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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以下溶剂前显示的百
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