CAS NO: | 52212-02-9 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitivenAChRantagonist with aKdof 3.06 μM[1][2][3][4][5]. | ||||||||||||||||
IC50& Target | nAChR[4][5] | ||||||||||||||||
体外研究 (In Vitro) | Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium[1]. | ||||||||||||||||
体内研究 (In Vivo) | The average ED95is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED95, and anaphylaxis does not appear to be a problem[2]. | ||||||||||||||||
分子量 | 762.70 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C35H62Br2N4O4 | ||||||||||||||||
CAS 号 | 52212-02-9 | ||||||||||||||||
中文名称 | 哌库溴铵 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 150 mg/mL(196.67 mM;Need ultrasonic) H2O : 100 mg/mL(131.11 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |