您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Pipecuronium bromide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Pipecuronium bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pipecuronium bromide图片
CAS NO:52212-02-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
哌库溴铵
产品介绍
Pipecuronium bromide 是一种有效的长效非去极化甾体神经肌肉阻滞剂 (NMBA),是一种双季铵化合物。Pipecuronium bromide 是一种功能强大的竞争性nAChR拮抗剂,Kd为 3.06 μM。
生物活性

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitivenAChRantagonist with aKdof 3.06 μM[1][2][3][4][5].

IC50& Target

nAChR[4][5]

体外研究
(In Vitro)

Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium[1].

体内研究
(In Vivo)

The average ED95is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED95, and anaphylaxis does not appear to be a problem[2].
Carboxymethylated γ-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment[3].

分子量

762.70

性状

Solid

Formula

C35H62Br2N4O4

CAS 号

52212-02-9

中文名称

哌库溴铵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 150 mg/mL(196.67 mM;Need ultrasonic)

H2O : 100 mg/mL(131.11 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.3111 mL6.5557 mL13.1113 mL
5 mM0.2622 mL1.3111 mL2.6223 mL
10 mM0.1311 mL0.6556 mL1.3111 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。