CAS NO: | 1839519-57-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator ofnAChRs(nicotinic acetylcholine receptors) with α2β2,α2β4,α4β2,α4β4,(α4β2)2α4 and (α4β2)2β2EC50ranges from 0.1~0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1]. |
IC50& Target | nAChRs[1] |
体外研究 (In Vitro) | Br-PBTC (0.01~10 μM; HEK cells) selectively affects 2 and 4 subunits. Br-PBTC (3 μM; oocytes) has greater effects on nAChRs with 2 subunits over those with 4 subunits. Br-PBTC (0.01~10 μM; 15 minutes; HEK cells) can increase channel activation by a maximal concentration of ACh. Br-PBTC (3 μM; 50 seconds; oocytes) increased ACh activation of α4β2 nAChRs by 385± 61 %. Br-PBTC (3 μM;oocytes) reactivates short term desensitized nAChRs expressed. Br-PBTC (3 μM; 500 seconds; HEK cells) reactivates short term desensitized (α4β2)2α4 and(α4β2)2β2 nAChRs expressed. Br-PBTC (0.1~100 μM;0~140 seconds; HEK cells) reactivates long term desensitized nAChRs[1]. |
分子量 | 339.25 |
Formula | C14H15BrN2OS |
CAS 号 | 1839519-57-1 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |