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Br-PBTC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Br-PBTC图片
CAS NO:1839519-57-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Br-PBTC 是一种有效的,2/4 亚型选择性的nAChRs(烟碱乙酰胆碱受体)的正变构调节剂,其 α2β2,α2β4,α4β2,α4β4,(α4β2)2α4 和 (α4β2)2β2EC50范围为 0.1~0.6 μM。Br-PBTC 从 α 亚基的 c 尾起作用。
生物活性

Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator ofnAChRs(nicotinic acetylcholine receptors) with α2β2,α2β4,α4β2,α4β4,(α4β2)2α4 and (α4β2)2β2EC50ranges from 0.1~0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1].

IC50& Target

nAChRs[1]

体外研究
(In Vitro)

Br-PBTC (0.01~10 μM; HEK cells) selectively affects 2 and 4 subunits. Br-PBTC (3 μM; oocytes) has greater effects on nAChRs with 2 subunits over those with 4 subunits. Br-PBTC (0.01~10 μM; 15 minutes; HEK cells) can increase channel activation by a maximal concentration of ACh. Br-PBTC (3 μM; 50 seconds; oocytes) increased ACh activation of α4β2 nAChRs by 385± 61 %. Br-PBTC (3 μM;oocytes) reactivates short term desensitized nAChRs expressed. Br-PBTC (3 μM; 500 seconds; HEK cells) reactivates short term desensitized (α4β2)2α4 and(α4β2)2β2 nAChRs expressed. Br-PBTC (0.1~100 μM;0~140 seconds; HEK cells) reactivates long term desensitized nAChRs[1].

分子量

339.25

Formula

C14H15BrN2OS

CAS 号

1839519-57-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.