您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Biricodar
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Biricodar
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biricodar图片
CAS NO:159997-94-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
VX-710
产品介绍
Biricodar (VX-710) 是P-glycoproteinMRP-1的调节剂; 在多药耐药细胞中显示出有效的化学敏化活性。
生物活性

Biricodar (VX-710) is a modulator ofP-glycoproteinandMRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

体外研究
(In Vitro)

Biricodar shows activity against both P-glycoprotein (Pgp) and MRP-1 and also has activity in increasing drug uptake and retention and reversing drug resistance mediated by wild-type BCRP (BCRPR482). In 8226/Dox6 cells (Pgp), biricodar increases mitoxantrone and daunorubicin uptake by 55 and 100%, respectively, increases their retention by 100 and 60%, respectively, and increases their cytotoxicity 3.1- and 6.9-fold, respectively. Biricodar also increases the uptake, retention and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)), but has little effect in MCF7 AdVP3000 cells (BCRP(R482T))[1]. VX-710 is a non-macrocyclic pipecolinate derivative which binds the FK506 receptor protein. VX-710 has been shown to restore sensitivity in a range of multidrug-resistant cells, including myeloma, melanoma, carcinoma and leukaemia[2]. Biricodar effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin with EC50values of 0.75 and 0.55 μM[3].

Clinical Trial
分子量

603.71

性状

Oil

Formula

C34H41N3O7

CAS 号

159997-94-1

中文名称

比立考达

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month