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Sinapine hydroxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sinapine hydroxide图片
CAS NO:122-30-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Sinapine hydroxide 是一种从十字花科物种的种子中分离出来的生物碱。Sinapine hydroxide 具有抗炎,抗氧化,抗肿瘤,抗血管生成和放射防护作用。Sinapine hydroxide 还是一种乙酰胆碱酯酶(AChE)抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。
生物活性

Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also anacetylcholinesterase (AChE)inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

IC50& Target

AChE[4], P-gp[1]

体外研究
(In Vitro)

Sinapine (6 or 60 μM; 1 h) counteracts H2O2and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3].

体内研究
(In Vivo)

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota[2].

分子量

327.37

Formula

C16H25NO6

CAS 号

122-30-5

结构分类
  • Alkaloids
  • Other Alkaloids
  • Phenols
  • Monophenols
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.