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8-Bromo-ATP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8-Bromo-ATP图片
CAS NO:23567-97-7
包装:1mg

产品名称
8-Bromoadenosine 5'-triphosphate
8-Br-ATP
产品介绍
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate),一种 ATP 类似物,是一种嘌呤能P2X receptor受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性,IC50为 23.1 μM。
生物活性

8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergicP2X receptoragonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with anIC50of 23.1 μM[1][2][3].

体外研究
(In Vitro)

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma[3].
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations[2].

Cell Viability Assay[3]

Cell Line:MM 1.s cells
Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time:5 days
Result:Showed cytotoxic to multiple myeloma.
分子量

586.08

Formula

C10H15BrN5O13P3

CAS 号

23567-97-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.