CAS NO: | 113559-13-0 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | E-4031 is a selectivehERGpotassium channelblocker for use in class III anti-arrhythmic studies[1]. | ||||||||||||||||
体外研究 (In Vitro) | E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits[2]. | ||||||||||||||||
体内研究 (In Vivo) | E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles[1]. | ||||||||||||||||
分子量 | 474.44 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H29Cl2N3O3S | ||||||||||||||||
CAS 号 | 113559-13-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : ≥ 50 mg/mL(105.39 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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