CAS NO: | 1391737-01-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | VU0463271 is a selectiveKCC2antagonist, with anIC50of 61 nM. | ||||||||||||||||
IC50& Target | IC50: 61 nM (KCC2)[1]. | ||||||||||||||||
体外研究 (In Vitro) | VU0463271 is a potent antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels and transporters. It is also found rapidly cleared in vitro[1]. | ||||||||||||||||
体内研究 (In Vivo) | VU0463271 is found to be a moderate-to-high clearance compound in rat (CL=57 mL/min/kg) following intravenous administration (1 mg/kg); the low volume of distribution at steady state (Vss 0.4 L/kg), coupled with moderate-to-high clearance produce a relatively short t1/2 (9 min) in vivo[1]. | ||||||||||||||||
分子量 | 382.50 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H18N4OS2 | ||||||||||||||||
CAS 号 | 1391737-01-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(65.36 mM;Need ultrasonic) 配制储备液
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