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PNU 37883 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PNU 37883 hydrochloride图片
CAS NO:57568-80-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
PNU 37883A
产品介绍
PNU 37883 hydrochloride (PNU 37883A) 是一种选择性血管 ATP 敏感钾 (Kir6, KATP) 通道阻滞剂。PNU 37883 hydrochloride 具有利尿作用,特异性结合肾脏和血管平滑肌,而不是大脑或胰腺 β 细胞。
生物活性

PNU 37883 hydrochloride (PNU 37883A) is a selectivevascular ATP-sensitive potassium (Kir6, KATP) channelsblocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].

体外研究
(In Vitro)

In HEK-293 cells stably expressing Kir6.2/SUR1, Kir6.2/SUR2A, Kir6.2/SUR2B or Kir6.1/SUR2B, PNU-37883A inhibits four types of KATP channels, but to different extents. Inhibition of the putative smooth muscle KATP channel types, Kir6.2/SUR2B (IC50 of 15 μM) and Kir6.1/SUR2B (IC50 of 6 μM). PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone, with an IC50 of 5 μM, which was significantly increased to 38 μM when Kir6.2Δ26 is expressed with SUR2B[1].
PNU 37883 (0.1-10 nM) hydrochloride produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings. However, treatment with PNU 37883 (10 nM) hydrochloride alone does not modify the vascular tone[3].

分子量

381.98

Formula

C21H36ClN3O

CAS 号

57568-80-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.