CAS NO: | 18711-16-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | NS309 is a potent and selective activator of theCa2+-activated SK/IK potassium channels, but displays no activity at BK channels[1][2][3][4]. | ||||||||||||||||
IC50& Target | EC50: 0.62 μM (SK2)[1], 0.3 μM (SK3)[2], ~20 nM (KCa3.1/SK4)[3], ~600 nM (KCa2/SK channels)[3], 10 nM (hIK)[4] | ||||||||||||||||
体外研究 (In Vitro) | NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels)[2]. | ||||||||||||||||
体内研究 (In Vivo) | NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits[6].
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分子量 | 231.04 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C8H4Cl2N2O2 | ||||||||||||||||
CAS 号 | 18711-16-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(432.83 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |