Quinidine polygalacturonate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

27555-34-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Quinidine polygalacturonate 是一种抗心律失常剂。Quinidine polygalacturonate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K⁺通道 (K⁺channel) 的有效阻断剂，其IC₅₀值为 19.9 μM，也可诱导凋亡。Quinidine polygalacturonate 也可用作疟疾的研究。

生物活性

Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selectivecytochrome P450dbinhibitor. Quinidine polygalacturonate is also aK⁺channelblocker with anIC₅₀of 19.9 μM, and can induceapoptosis. Quinidine polygalacturonate can be used for malaria research^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Quinidine polygalacturonate shows cytotoxicity against MES-SA cells, and induces apoptosis^[4].

Apoptosis Analysis^[4]

Cell Line:	MES-SA and MESSA/DX5 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.

Cell Cytotoxicity Assay^[4]

Cell Line:	MES-SA and MESSA/DX5 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

体内研究
(In Vivo)

Quinidine polygalacturonate shows effects on the PTZ-induced seizure threshold^[5].

Animal Model:	Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)^[5]
Dosage:	10, 20, and 30 mg/kg
Administration:	Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result:	Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).

Clinical Trial

Formula

C₂₆H₃₄N₂O₉

CAS 号

27555-34-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.