TRPV3 antagonist 74a

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CAS NO:	1432051-63-2
包装:	5mg

产品介绍

TRPV3 antagonist 74a 是一种有效的选择性TRPV3拮抗剂。TRPV3 antagonist 74a 对其他离子通道面板显示无显著活性。TRPV3 antagonist 74a 可用于神经性疼痛的研究。

生物活性

TRPV3 antagonist 74a is a potent and selectiveTRPV3antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain^[1]^[2].

IC₅₀& Target^[1]^[2]

TRPV3

体外研究
(In Vitro)

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca²⁺responses^[2].

体内研究
(In Vivo)

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly^[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold^[1].

Animal Model:	WT mice
Dosage:	150 μg
Administration:	Intradermal injection; 30 minutes
Result:	The number of scratches decreased significantly.

分子量

338.32

Formula

C₁₇H₁₇F₃N₂O₂

CAS 号

1432051-63-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.