SAR7334

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SAR7334

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1333210-07-3

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

SAR7334 是一种有效的TRPC6特异性抑制剂，能够抑制 TRPC6 电流，IC₅₀值为 7.9 nM。

生物活性

SAR7334 is a potent and specificTRPC6inhibitor, inhibiting TRPC6 currents withIC₅₀of 7.9 nM.

IC₅₀& Target

IC50: 7.9 nM (TRPC6 currents)^[3]

体外研究
(In Vitro)

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺influx into cells with IC₅₀s of 9.5, 282 and 226 nM^[1]^[2]^[3], whereas TRPC4 and TRPC5-mediated Ca²⁺entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes^[1]. SAR7334 (1 μM) has negligible effect on SOCE^[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents^[3].

体内研究
(In Vivo)

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)^[3].

分子量

367.87

性状

Solid

Formula

C₂₁H₂₂ClN₃O

CAS 号

1333210-07-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 370 mg/mL(1005.79 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7184 mL	13.5918 mL	27.1835 mL
5 mM	0.5437 mL	2.7184 mL	5.4367 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。