CAS NO: | 480-66-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained fromCurcuma comosaRoxb, with cholesterol-lowering activity. Phloracetophenone enhancescholesterol7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated throughMrp2[2]. | ||||||||||||||||
IC50& Target | Cholesterol 7α-hydroxylase[1], Mrp2[2] | ||||||||||||||||
体外研究 (In Vitro) | Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. | ||||||||||||||||
体内研究 (In Vivo) | Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2]. | ||||||||||||||||
分子量 | 168.15 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C8H8O4 | ||||||||||||||||
CAS 号 | 480-66-0 | ||||||||||||||||
中文名称 | 2',4',6'-三羟基苯乙酮 一水合物 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(148.68 mM;Need ultrasonic) H2O : 2 mg/mL(11.89 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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