CAS NO: | 1332391-11-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of theandrogen receptorand is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strongCYP3A4andCYP2B6inducer and has an excellent plasma-proteins bound concentration[1][2][3]. | ||||||||||||||||
IC50& Target | CYP3A4 and CYP2B6[1]; Androgen receptor[2] | ||||||||||||||||
分子量 | 463.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H13F4N5O2S | ||||||||||||||||
CAS 号 | 1332391-11-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(215.79 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |