您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Vildagliptin dihydrate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Vildagliptin dihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vildagliptin dihydrate图片
CAS NO:2133364-01-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
维格列汀二水合物
LAF237 dihydrate
NVP-LAF 237 dihydrate
产品介绍
Vildagliptin dihydrate (LAF237 dihydrate) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。Vildagliptin dihydrate 具有出色的口服生物利用度和有效的降血糖活性。
生物活性

Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selectivedipeptidyl peptidaseIV (DPP-IV) inhibitor with anIC50of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

IC50& Target

IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]

体外研究
(In Vitro)

Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

体内研究
(In Vivo)

Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
Vildagliptin (10 μmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

Animal Model:Male db/db mice (BKS) and wildtype mice[2]
Dosage:35 mg/kg
Administration:Oral gavage; once daily; for 6 weeks
Result:Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
Animal Model:Obese male Zucker rats[1]
Dosage:10 μmol/kg (Pharmacokinetic Analysis)
Administration:Orally
Result:Significantly decreased glucose excursions and stimulate insulin secretion.
Clinical Trial
分子量

339.43

Formula

C17H29N3O4

CAS 号

2133364-01-7

中文名称

维达列汀二水合物;维格列汀二水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.