CAS NO: | 709031-78-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally activedipeptidyl peptidase-4 (DPP-4)(Ki= 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research[1][2][3]. | ||||||||||||||||
IC50& Target | Ki: 0.6-1.3 nM (Dipeptidyl peptidase-4 (DPP-4))[2] | ||||||||||||||||
体外研究 (In Vitro) | Saxagliptin (100 nM; 48 hours; INS-1 832/13 cells) treatment significantly induceS β-cell proliferation[1]. Cell Viability Assay[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) | Saxagliptin (1 mg/kg; for 12 weeks) treatment in high-fat diet/streptozotocin-induced diabetic rats, significant improvement in pancreas insulin secretion capacity evaluated by hyperglycemia clamp and increased β-cell to α-cell areas ratio are observed[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 351.87 | ||||||||||||||||
Formula | C18H26ClN3O2 | ||||||||||||||||
CAS 号 | 709031-78-7 | ||||||||||||||||
中文名称 | 盐酸沙格列汀;盐酸沙克列汀 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |