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4-Vinylphenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-Vinylphenol图片
CAS NO:2628-17-3
包装:100mg (832.2 mM * 1 mL in Propylene glycol)
市场价:500元

产品名称
4-乙烯基苯酚
产品介绍
4-Vinylphenol 存在于药用草白花蛇舌草,野生稻中,也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol 诱导凋亡 (apoptosis),在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。
生物活性

4-Vinylphenol is found in the medicinal herbHedyotis diffusaWilld, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol inducesapoptosisand inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

4-Vinylphenol (12.5-200 μg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 μg/mL[1].
4-Vinylphenol (0.15 or 0.3 μg/mL; 3 days) reduces sphere-formation and vimentin expression on CSCs in breast cancer[1].
4-Vinylphenol (50, 100 μg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells[1].
4-Vinylphenol (100 μg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis[1].

分子量

120.15

性状

Liquid

Formula

C8H8O

CAS 号

2628-17-3

中文名称

4-乙烯基苯酚

结构分类
  • Phenols
  • Monophenols
来源
  • Plants
  • Rubiaceae
  • Hedyotis diffusaWilld.

recombinant Streptomyces mobaraense

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years