CAS NO: | 2765180-17-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Antitumor agent-81 (compound 5a) is a low cytotoxicP62-RNF168agonist that promotes the interaction ofP62withRNF168. Antitumor agent-81 induces a decrease inRNF168-mediatedH2Aubiquitination and impairs homologous recombination-mediated DNA repair. Antitumor agent-81 also inhibits mice xenograft tumor growth in a dose-dependent manner[1]. | ||||||||||||||||||||||||||||||||||||
体外研究 (In Vitro) | Antitumor agent-81 (0-20 μM; 72 h) exhibits antiproliferative activity in cells of the most common cancer types[1]. Cell Proliferation Assay[1]
Cell Cycle Analysis[1]
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体内研究 (In Vivo) | Antitumor agent-81 (5, 10 mg/kg; i.p.; single every 3 days for 22 days) suppresses tumor volumes in a dose-dependent manner in mice[1].
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分子量 | 393.40 | ||||||||||||||||||||||||||||||||||||
Formula | C19H19N7O3 | ||||||||||||||||||||||||||||||||||||
CAS 号 | 2765180-17-2 | ||||||||||||||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |