CAS NO: | 1361217-07-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | AMG-1694 is a potentglucokinase–glucokinase regulatory protein (GK-GKRP)disruptors and promotes the dissociation of the GK-GKRP complex with anIC50of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemicanimals[1]. |
IC50& Target | IC50: 7 nM (GK-GKRP)[1] |
体外研究 (In Vitro) | AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50of 0.020 μM in the presence of GKRP[1]. |
分子量 | 533.63 |
Formula | C23H30F3N3O4S2 |
CAS 号 | 1361217-07-3 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |