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AMG-1694
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AMG-1694图片
CAS NO:1361217-07-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AMG-1694 是一种有效的葡萄糖激酶-葡萄糖激酶调节蛋白(GK-GKRP)破坏剂,AMG-1694 促进 GK-GKRP 复合物的解离,IC50为 7 nM,间接增加 GK 酶活性。AMG-1694 有效地逆转 GKRP 对 GK 活性的抑制作用,并促进 GK 易位。AMG-1694 可在几种啮齿动物的糖尿病模型中使血糖水平正常化,并且只能降低糖尿病患者血糖而非血糖正常的动物。
生物活性

AMG-1694 is a potentglucokinase–glucokinase regulatory protein (GK-GKRP)disruptors and promotes the dissociation of the GK-GKRP complex with anIC50of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemicanimals[1].

IC50& Target

IC50: 7 nM (GK-GKRP)[1]

体外研究
(In Vitro)

AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50of 0.020 μM in the presence of GKRP[1].

分子量

533.63

Formula

C23H30F3N3O4S2

CAS 号

1361217-07-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.