CAS NO: | 1262132-81-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Enarodustat is a potent and orally activehypoxia-inducible factor prolyl hydroxylaseinhibitor, with anEC50of 0.22 μM. Enarodustat has the potential for renal anemia treatment. | ||||||||||||||||
IC50& Target | EC50: 0.22 μM (factor prolyl hydroxylase)[1] | ||||||||||||||||
体外研究 (In Vitro) | Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50of 0.22 μM. Enarodustat exhibits neither CYP (IC50>100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50>100 μM) inhibition[1]. | ||||||||||||||||
体内研究 (In Vivo) | Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 340.33 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H16N4O4 | ||||||||||||||||
CAS 号 | 1262132-81-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 83.33 mg/mL(244.85 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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