CAS NO: | 331830-20-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | 1,4-DPCA, a potentprolyl-4-hydroxylaseinhibitor, is acollagen hydroxylationinhibitor in human foreskin fibroblasts with anIC50of 2.4 μM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibitsfactor inhibiting HIF (FIH)with anIC50of 60 μM[1][2]. | ||||||||||||||||
IC50& Target | IC50: 2.4 μM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))[2] | ||||||||||||||||
体外研究 (In Vitro) | 1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | 1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition[2]. | ||||||||||||||||
分子量 | 240.21 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C13H8N2O3 | ||||||||||||||||
CAS 号 | 331830-20-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(52.04 mM;Need ultrasonic) 配制储备液
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