您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Simvastatin hydroxy acid sodium
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Simvastatin hydroxy acid sodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Simvastatin hydroxy acid sodium图片
CAS NO:101314-97-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
辛伐他汀钠盐
Tenivastatin sodium
Simvastatin Impurity A sodium
产品介绍
Simvastatin hydroxy acid (Tenivastatin) sodium 是一种有效的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin hydroxy acid sodium 降低吲哚酚硫酸盐 (Indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin hydroxy acid sodium 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。
生物活性

Simvastatin hydroxy acid (Tenivastatin) sodium is a potentHMG-CoA reductase(HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediatedreactive oxygen species(ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

IC50& Target

HMG-CoA reductase, Reactive oxygen species[1][2]

体外研究
(In Vitro)

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].

Western Blot Analysis[2]

Cell Line:hCM and HEK293 (transfected with OATP3A1)
Concentration:0.1, 1, 10 and 20 μM
Incubation Time:24 h
Result:Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
分子量

458.56

Formula

C25H39NaO6

CAS 号

101314-97-0

中文名称

辛伐他汀EP杂质A Sodium Salt

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.