MMP-9-IN-5 是一种MMP-9抑制剂 (IC50: 4.49 nM)，可与 MMP-9 形成氢键。MMP-9-IN-5 还抑制AKT活性 (IC50: 1.34 nM)。MMP-9-IN-5 具有细胞毒性并诱导细胞凋亡 (apoptosis)。MMP-9-IN-5 可用于癌症研究。
| 生物活性 | MMP-9-IN-5 is aMMP-9inhibitor (IC50: 4.49 nM) that forms hydrogen bond withMMP-9. MMP-9-IN-5 also inhibitsAKTactivity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cellapoptosis. MMP-9-IN-5 can be used in the research of cancers[1]. |
| IC50& Target[1] | MMP-9 4.49 nM (IC50) | MMP-1 104 nM (IC50) | MMP-2 266 nM (IC50) | MMP-13 280 nM (IC50) | AKT 1.34 nM (IC50) |
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体外研究
(In Vitro) | MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1].
MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1].
MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
Cell Viability Assay[1] | Cell Line: | Wi-38, MCF-7, NFS-60, HepG-2 cells | | Concentration: | 0-1 μM approximately | | Incubation Time: | 72 h | | Result: | Showed cytotoxicity with IC50s: 35.1 nM (Wi-38), 6.9 nM (MCF-7), 5.5 nM (NFS-60), 3.1 nM (HepG-2). |
Cell Migration Assay[1] | Cell Line: | HepG-2 | | Concentration: | 3.1 nM | | Incubation Time: | 24 h | | Result: | Inhibited cell migration by 59.35%. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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