CAS NO: | 1435779-45-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally activemetalloproteinase (MMP)inhibitor withIC50s of 79, 6.3 and 5.0 nM forMMP-1,MMP-3andMMP-9, respectively. Prinomastat hydrochloride inhibitsMMP-2,MMP-3andMMP-9withKis of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity[1][2][3][4]. | ||||||||||||||||
IC50& Target[1][4] |
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体外研究 (In Vitro) | Prinomastat (AG3340; 0.1-1 μg/mL; 4 days; C57MG/Wnt1 cells) inhibits Wnt1-induced MMP-3 production. Reversal of Wnt1-induced EMT and β-catenin transcriptional activity by Prinomastat[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | In a human fibrosarcoma mouse model (HT1080), the mice are treated therapeutically for 14-16 days with 50 mg/kg/day ip daily starting day 3 to 6 after tumour inoculation. Prinomastat is well tolerated by the animals, and there are no signs of weight loss or other adverse effects. Prinomastat has good tumour growth inhibition, with a short T1/2of 1.6 hours[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 459.97 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H22ClN3O5S2 | ||||||||||||||||
CAS 号 | 1435779-45-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(217.41 mM;Need ultrasonic) H2O : 50 mg/mL(108.70 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |