MMP-9-IN-4 是一种MMP-9抑制剂 (IC50: 7.46 nM)，与 MMP-9 形成 H-π 相互作用。MMP-9-IN-4 还抑制AKT活性 (IC50: 8.82 nM)。MMP-9-IN-4 具有细胞毒性并诱导细胞凋亡 (apoptosis)。MMP-9-IN-4 可用于癌症研究。
| 生物活性 | MMP-9-IN-4 is aMMP-9inhibitor (IC50: 7.46 nM) that has H-π interactions withMMP-9. MMP-9-IN-4 also inhibitsAKTactivity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cellapoptosis. MMP-9-IN-4 can be used in the research of cancers[1]. |
| IC50& Target[1] | MMP-9 7.46 nM (IC50) | MMP-1 41 nM (IC50) | MMP-2 139 nM (IC50) | MMP-13 113 nM (IC50) | AKT 8.82 nM (IC50) |
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体外研究
(In Vitro) | MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1].
MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1].
MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM[1].
Cell Viability Assay[1] | Cell Line: | Wi-38, MCF-7, NFS-60, HepG-2 cells | | Concentration: | 0-1 μM approximately | | Incubation Time: | 72 h | | Result: | Showed cytotoxicity with IC50s: 374 nM (Wi-38), 3.6 nM (MCF-7), 3.61 nM (NFS-60), 2.2 nM (HepG-2). |
Cell Migration Assay[1] | Cell Line: | HepG-2 | | Concentration: | 2.2 nM | | Incubation Time: | 24 h | | Result: | Inhibited cell migration by 93.77%. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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