PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinaseMMP-12(IC₅₀=1.4 μM). PF-00356231 hydrochloride binds toMMP-12and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency againstMMP-13,MMP-8,MMP-9,MMP-3withIC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively^[1].

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC₅₀values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH^[1].

464.96

Solid

C₂₅H₂₁ClN₂O₃S

820223-77-6

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 20.83 mg/mL(44.80 mM;ultrasonic and warming and heat to 60℃)

H₂O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。