| CAS NO: | 179545-77-8 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenylmatrix metalloproteinases(MMPs)inhibitor with a Zn-binding carboxyl group. TheKivalues are 11, 143, 301, and 1470 nM forMMP-2,MMP-3,MMP-9,MMP-13respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3]. | |||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2]. | |||||||||
| 体内研究 (In Vivo) | Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3].
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| 分子量 | 410.91 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C23H19ClO3S | |||||||||
| CAS 号 | 179545-77-8 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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