CP-544439 is a potent and orally active matrix metalloproteinase-13(MMP-13)inhibitor with anIC₅₀of 0.75 nM^[1][2].

In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED₅₀of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml^[1].

410.42

C₁₈H₁₉FN₂O₆S

230954-09-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.