CAS NO: | 866924-39-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GW280264X is the mixedADAM10/TACE (ADAM17) metalloproteinasesinhibitor. GW280264X potently blocksTACE (ADAM17)andADAM10withIC50s of 8.0 nM and 11.5 nM, respectively[1].ADAM10and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown[2]. Cell Viability Assay[2]
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体内研究 (In Vivo) | Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3].
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分子量 | 575.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H41N5O6S | ||||||||||||||||
CAS 号 | 866924-39-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(217.12 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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