PI3K/AKT-IN-2 (Compound 12c) is aPI3KandAKTinhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and inducesapoptosis. PI3K/AKT-IN-2 inhibits the polymerization oftubulin^[1].

PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC₅₀values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 μM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively^[1].
PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)– 2, vimentin and up-regulation E-cadherin^[1].
PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C^[1].

651.45

C₃₂H₂₇BrO₁₀

2684412-41-5

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