您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Okadaic Acid Ammonium Salt
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Okadaic Acid Ammonium Salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Okadaic Acid Ammonium Salt图片
CAS NO:175522-42-6
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
冈田酸铵盐
产品介绍
Okadaic acid ammonium salt 是一种海洋毒素，是蛋白质磷酸酶(PP)的抑制剂，包括PP1(IC50=15-50 nM)、PP2A(IC50=0.1-0.3 nM)、PP3(IC50=3.7-4 nM)、PP4(IC50=0.1 nM) 和PP5(IC50=3.5 nM)，其中对 PP2A 的亲和力最显著，但不抑制 PP2C。Okadaic acid ammonium salt 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。Okadaic acid ammonium salt 诱导 tau 蛋白磷酸化。
生物活性

Okadaic acid ammonium salt, a marine toxin, is an inhibitor ofprotein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity forPP2A(IC50=0.1-0.3 nM), and inhibitsPP1(IC50=15-50 nM),PP3(IC50=3.7-4 nM),PP4(IC50=0.1 nM),PP5(IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation[1][2].

IC50& Target[1]

PP1

15-50 nM (IC50)

PP2A

0.1-0.3 nM (IC50)

PP3

3.7-4 nM (IC50)

PP4

0.1 nM (IC50)

PP5

3.5 nM (IC50)

PP2B

~4000 nM (IC50)

PP7

＞1000 nM (IC50)

体外研究
(In Vitro)

Okadaic acid ammonium salt (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM, 8 hours) ammonium salt increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

Cell Proliferation Assay[3]

Cell Line:AGS, MNK-45 and Caco 2 cell lines
Concentration:0-100 nM
Incubation Time:24 h or 48 h
Result:Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
体内研究
(In Vivo)

Okadaic acid ammonium salt (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5].

Animal Model:Female wild-type C57BL/6 mice (6 to 8 months)[5]
Dosage:100 μM
Administration:Injected unilaterally to the lateral amygdala
Result:Induced Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection.
分子量

822.03

Formula

C44H71NO13

CAS 号

175522-42-6

中文名称

冈田酸铵盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.