FIPI is a derivative of halopemide which potently inhibits bothPLD1andPLD2withIC₅₀s of 25 nM and 20 nM, respectively.

IC50: 25 nM (PLD1), 20 nM (PLD2)

Despite the high clearance of greater than 2 L/h/kg, FIPI shows a half-life of greater than 5 h, a Cmax of greater than 10-fold the₅₀versus PLD2, and moderate bioavailability of 18%^[1]. FIPI inhibits both PLD1 and PLD2 in a dose-dependent manner, with 50% loss of activity observed at approximately 25 nM. FIPI is not an irreversible suicide inhibitor but neither is it rapidly and completely reverses upon removal of the drug. IPI does not alter PLD subcellular localization, access to PIP2, actin stress fibers, or upstream signaling events. FIPI rescues PLD2-suppressed membrane ruffling and cell spreading^[2]. FIPI attenuats the thimerosal-induced PLD activation, and the Hg-induced PLD activation in MAECs in a dose-dependent manner, and the agonist- and oxidant-induced PLD activation in a dose-dependent manner in MAECs^[3].

421.47

Solid

C₂₃H₂₄FN₅O₂

939055-18-2

5-氟-2-吲哚基脱氯卤培米特

Room temperature in continental US; may vary elsewhere.

DMSO : 14.67 mg/mL(34.81 mM;Need ultrasonic and warming)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。