FKGK11 is a potent and selective inhibitor ofGVIA iPLA2(Group VIA calcium-independentphospholipaseA2). FKGK11 can be used for the research of ovariancancerand neurological disorders such as peripheral nerve injury and multiple sclerosis^[1][2].

FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction^[1].
FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells^[2].

FKGK11 inhibits tumor development in the xenograft mouse model^[2].
FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA–/– mice and C57BL/6 mice^[3].

280.23

C₁₃H₁₃F₅O

1071000-98-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.