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Protizinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protizinic acid图片
CAS NO:13799-03-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
丙替嗪酸
产品介绍
Protizinic acid 是一种具有口服活性的非甾体抗炎剂,具有抗炎和解热活性。Protizinic acid 抑制磷脂酶 A2 (PLA2) 活性,IC50值为 210 μM。
生物活性

Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibitsphospholipaseA2 (PLA2)activity, and theIC50value is 210 μM[1][2].

IC50& Target[2]

PLA2

210 μM (IC50)

体外研究
(In Vitro)

Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin[1].

体内研究
(In Vivo)

In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1].
Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].

分子量

315.39

Formula

C17H17NO3S

CAS 号

13799-03-6

中文名称

丙替嗪酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.