CAS NO: | 20449-79-0 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
生物活性 | Melittin is aPLA2activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2[1][2]. | ||||||||||||||||||||
IC50& Target | PLA2[1] | ||||||||||||||||||||
体外研究 (In Vitro) | Melittin, an immunologically related PLA2stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme[1]. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2]. | ||||||||||||||||||||
分子量 | 2846.46 | ||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||
Formula | C131H229N39O31 | ||||||||||||||||||||
CAS 号 | 20449-79-0 | ||||||||||||||||||||
Sequence | Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 | ||||||||||||||||||||
Sequence Shortening | GIGAVLKVLTTGLPALISWIKRKRQQ-NH2 | ||||||||||||||||||||
中文名称 | 蜂毒肽;蜂毒素 | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 |
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Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table:
3. Recommended solution:
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