Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator ofphospholipaseA2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hindersfungalgrowth by inducing cellapoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways^[1][2].

Melittin free acid 刺激小鼠纤维细胞 (MC5-5)、人成纤维细胞 (D550)、兔主动脉内皮细胞 (CLO)、大鼠肺型肺泡肺细胞 (L-2) 和兔平滑肌细胞 (R-I) 的前列腺素生物合成^[1]。
Melittin free acid 刺激 MC5-5 细胞磷脂中花生四烯酸的释放^[1]。
Melittin free acid 诱导黄曲霉萌发分生孢子中活性氧的积累^[2]。
Melittin 抑制灰霉菌 MUCL 30158 和 CECT 2100 菌株，IC₅₀值分别为 3.1 和 24 μM^[2]。

Melittin (腹腔内接种) 可增加小鼠外周血中 13,14-dihydro-15-keto-PGE2 的水平^[1]。

2847.45

C₁₃₁H₂₂₈N₃₈O₃₂

123168-46-7

GIGAVLKVLTTGLPALISWIKRKRQQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.