| CAS NO: | 34298-86-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 34298-86-7 |
| 别名 | 大黄酸 8-葡糖苷; Rhein 8-O-β-D-Glucopyranoside |
| Canonical SMILES | O=C1C2=C(C=C(C(O)=O)C=C2O)C(C3=CC=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C31)=O |
| 分子式 | C21H18O11 |
| 分子量 | 446.4 |
| 溶解度 | DMSO: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.1 It increases the rate of sennoside A metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).2 Rhein-8-glucoside is metabolized to rhein by intestinal bacteria.1 |1. Takayama, K., Tsutsumi, H., Ishizu, T., et al. The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice. Biol. Pharm. Bull. 35(12), 2204-2208 (2012).|2. Li, S., An, T.-Y., Li, J., et al. PTP1B inhibitors from Saussrurea lappa. J. Asian Nat. Prod. Res. 8(3), 281-286 (2006). |
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