CAS NO: | 895542-09-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Trifarotene (CD5789) is a potent and selectiveRARγagonist. Trifarotene (CD5789) shows ~65-fold and ~16-fold selectivitiy for theRARγ(EC50=7.7 nM) overRARα(EC50=500 nM) andRARβ(EC50=125 nM), respectively[1]. | ||||||||||||||||
体外研究 (In Vitro) | Trifarotene (CD5789) (3.3 μL 0.33 cm2; 24 hours) involves in keratinization, desquamation, cornification and cell adhesion in reconstructed human epidermis (RHE). The mean EC50on the combined target genes is 0.0048% for Trifarotene[2]. | ||||||||||||||||
体内研究 (In Vivo) | Trifarotene (0.001%-0.01% in a cream at 25 mg/mouse) shows dose-dependent comedolytic activity, being fully efficacious at 0.01% (98% reduction)[2].
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Clinical Trial | |||||||||||||||||
分子量 | 459.58 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H33NO4 | ||||||||||||||||
CAS 号 | 895542-09-3 | ||||||||||||||||
中文名称 | 曲法罗汀 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(543.97 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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