Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potentRARagonist, withAC₅₀s of 2.3 nM, 9.3 nM, and 22 nM forRARβ,RARγ,RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity ofGOT1in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity^[1][2][3].

AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)^[1]

Adapalene sodium salt (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC₅₀s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively^[2].
Adapalene sodium salt (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro^[2].
Adapalene sodium salt (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells^[3].
Adapalene sodium salt (1-200 μM) inhibits GOT1 activity, with an IC₅₀ of 21.79 μM^[2].
Adapalene sodium salt (10^-6-10^-3nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC₅₀of 2.5 nM^[1].

Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice^[3].

434.50

C₂₈H₂₇NaO₃

911110-93-5

阿达帕林钠

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.