ACT 178882 is a newRenininhibitor with anIC₅₀of 1.4 nM.

IC50: 1.4 nM (Renin)^[1]

The median time to C_max(t_max) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t _1/2 ) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for C_maxand 2.02 (1.75 to 2.34) for AUC_∞, indicating a significant interaction between ACT 178882 and diltiazem^[2].

647.03

C₃₃H₃₈Cl₃N₃O₄

1007392-69-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.