all-trans-4-Oxoretinoic acid(all-trans 4-Keto Retinoic Acid)

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CAS NO:

38030-57-8

包装与价格：

产品介绍

all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) 是维生素 A 的一种活性代谢物，通过与核视黄酸受体 (RAR) 结合来诱导基因转录。

Cas No.	38030-57-8
别名	4-KETO全反式维甲酸,all-trans 4-Keto Retinoic Acid
Canonical SMILES	CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O
分子式	C₂₀H₂₆O₃
分子量	314.42
溶解度	DMSO : 150 mg/mL (477.07 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs)[1]. all-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid (RA) [2]. [1]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41. [2]. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.